Neutrophils are a crucial part of the innate immunity. Initial immune responses against pathogens are primarily neutrophil mediated. Neutrophil extracellular traps (NETs) are expelled following neutrophil stimulation. This process, called NETosis, can be highly protective. However, its’ non-specific nature results in upregulation of local pro-inflammatory stimuli and often in tissue injury. NETosis has been suggested to participate in the pathogenesis of many immune-mediated diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and psoriasis. Recently, a phytochemical isolated from ginger root was reported to inhibit NETosis and reduce levels of plasma NETs when administered orally to humans and mice.
Abstract
| Sotirios G. Tsiogkas*, Dimitrios P. Bogdanos |
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