Metagenome-wide association study reveales diseasespecific landscape of the gut microbiome of systemic lupus erythematosus: a constellation of dysbiosis and inflammation

Abstract

This commentary evidences the role of dysbiosis in patients with systemic lupus erythematosus (SLE). It was shown that specific Streptococcus spp. may exert a pathogenic role by empowering the gut inflammation, especially through the observation of a correlation with acylcarnitine. Nonetheless, geographical differences should be carefully taken into account since genetic, dietary and other lifestyle habits may influence the composition of gut microbiota. More in-depth investigations of this possible association are soon expected.

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