Chronic pain constitutes a major problem for patients and physicians alike. Deciphering the mechanisms driving the evolution of acute pain into chronic may provide ways for preventing this entity. A recent study showed that neutrophil-driven inflammation in patients with acute pain was associated with pain resolution, while administration of non-steroid anti-inflammatory drugs (NSAIDs) in a mouse model led to prolonged pain in the long run, as corroborated by a database analysis that showed an increased risk of chronic pain in patients having taken NSAIDs. The realization that neutrophil-driven inflammation may provide benefits has been shown in other medical settings as well; as such, abundantly administering anti-inflammatory compounds warrants more careful consideration and more studies like this are more than encouraged.
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