Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination: Food for Thought on Milk, Diet and Multiple Sclerosis
This commentary discusses a very interesting and well-executed study with clinical correlates, which showed a cross-reactivity pattern between casein, a protein of milk, and myelin-associated glycoprotein, as evidence of a possible involvement in multiple sclerosis pathogenesis. Casein-immunized mice showed antibody-mediated demyelination with complement activation, while casein-antibodies were found in significantly higher levels in patients with multiple sclerosis that in patients with other neurological disorders. These findings highlight that diet could play a determining role in multiple sclerosis, and also provides evidence to suggest that dairy restriction could confer clinical benefits. However, the existing evidence on the association between dairy intake and multiple sclerosis, or the effectiveness of dietary interventions remains contradictory and at preliminary stages. More in-depth investigations of this possible association and studies in the effects of diet in multiple sclerosis patients are needed and more than encouraged.
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