This letter to the editor raises concerns as to whether anti-EBNA1 Epstein-Barr virus (EBV) antibodies could be the viral triggers of systemic lupus erythematosus (SLE). We grow some concerns and comment on that in view of a recent study speculating that indeed anti-EBNA1 antibodies are the likely primary initiators of SLE-specific autoantibodies via molecular mimicry. In our mind, their data are not as convincing as it would be expected to reach a consensus for a decisive role of EBV in provoking SLE.
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