Autoantibodies are frequently induced during SARS-Cov-2 infection, especially in patients suffered from sever COVID-19. The prevalence of autoantibodies ranges amongst studies but there is a consensus regarding the antigen-specificity of the observed humoral responses. These autoantibodies appear to be directed against known autoantigens, several of which are associated with organ and non-organ specific diseases, while others have not been previously considered significant triggers of autoimmunity and overt autoimmune disease. In this letter, we comment on a recently published study underlying the universal role of SARS-CoV-2 infection as an instrumental initiator for autoantibodies potentially directed against hundreds of autoantigens, several of whom are predictors of future development of an autoimmune diseases. Of pathogenic relevance, the findings of that study undescore a novel pathway used by the virus to initiate autoimmunity and indeed autoimmune disease.
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