T lymphocytes establish and maintain immune responses. T cell blood precursors under thymic signaling express TCR and CD4 or CD8 co-receptor and differentiate into naïve T cells. This educational note illustrates the major molecular processes that facilitate development of the double negative pre-thymic cell towards a mature T cell. Basic principles of each model, selective or instructive, trying to elucidate the biologic pressures under which T cell fate is determined are presented. The aim is those in need to better understand the basics of T cell fate choice.
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