The emergence of autoantibodies (AAbs) against self-antigens is an old story almost a hundred years old. On the contrary, only recently scientists started to shed light on the antigen-specific immune response in cancerous diseases. During the last decades numerous studies have revealed the significance and applications of autoantibodies in cancer. Cancer-evoked immunity has apparently dual role in either promoting or suppressing the neoplastic progression. Moreover, the implications of AAbs in early diagnosis as biomarkers are continually studied focusing on early detection of cancer and effective management. In this mini review, we mostly elaborate the possible contribution of autoantibodies in the diagnosis of cancer.
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